Bryan Haycock said:Mechanical Load is necessary to induce muscle hypertrophy. This mechanism involves but isn't limited to, MAPk/ERK, satellite cells, growth factors, calcium, and number of other fairly understood factors. It is incorrect to say "we don't know how muscle grows in response to training". The whole point of the HST book is not to discuss HST, but to present the body of research explaining how hypertrophy occurs. Then HST becomes a relatively obvious conclusion if your goal is hypertrophy.
Interesting difference in perspectiveBorge Fagerli said:...This is something that further research is still, for example in connection with the occlusion effect, but as I said above is a main variable that we achieve full fiber activation and then you get into such a lot of reps at this point that the mechanical workload to compensate for the lower mechanical strain. Studies have also shown that protein synthesis is identical at 60% of 1RM as at 90% of 1RM, but we also know that when the muscle is accustomed to a given load area so the contrast (from low to high or from high to low) may be necessary to create muscle growth. Komi et al showed a presentation on the ECSS where they did not see any significant increase in protein synthesis in advanced powerlifters even if we increased the amount of training at the heavier weights. When, however, exposed them to light weights (around 20RM) saw a growth response again. Had it only been about mechanical load would not be easier weights than those 3RM charges they trained with regularly could create such a response. It is NOK explanation for the Nonlinear / non-linear accrual of heavy / medium / light weights in the same treningsuke has proven to be more effective for advanced practitioners (as a linear progression is as effective for beginners and middle advanced). Muscle growth is so multifaktorielt that there is much we still do not know with certainty.
