lactic acid for tendon references

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imported_evilrussian

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Hi Brian!

Do you have (or anybody) the references supporting that lactic acid is good for tendon repair/health?

Thank You!
 
The references used by Bryan were largely based on wound repair and the work of Hunt and Husain.
Wagner S, Hussain MZ, Hunt TK, Bacic B, Becker HD.
Stimulation of fibroblast proliferation by lactate-mediated oxidants.
Wound Repair Regen. 2004 May-Jun;12(3):368-73.

Ghani QP, Wagner S, Becker HD, Hunt TK, Hussain MZ.
Regulatory role of lactate in wound repair.
Methods Enzymol. 2004;381:565-75.

Trabold O, Wagner S, Wicke C, Scheuenstuhl H, Hussain MZ, Rosen N,
Seremetiev A, Becker HD, Hunt TK.
Lactate and oxygen constitute a fundamental regulatory mechanism in wound
healing.
Wound Repair Regen. 2003 Nov-Dec;11(6):504-9.

Constant JS, Feng JJ, Zabel DD, Yuan H, Suh DY, Scheuenstuhl H, Hunt TK,
Hussain MZ.
Lactate elicits vascular endothelial growth factor from macrophages: a possible
alternative to hypoxia.
Wound Repair Regen. 2000 Sep-Oct;8(5):353-60.

Sheikh AY, Gibson JJ, Rollins MD, Hopf HW, Hussain Z, Hunt TK.
Effect of hyperoxia on vascular endothelial growth factor levels in a wound
model.
Arch Surg. 2000 Nov;135(11):1293-7.

Hunt TK, Hussain MZ.
Can wound healing be a paradigm for tissue repair?
Med Sci Sports Exerc. 1994 Jun;26(6):755-8.

Some others are

Klein MB, Pham H, Yalamanchi N, Chang J.
Flexor tendon wound healing in vitro: the effect of lactate on tendon cell
proliferation and collagen production.
J Hand Surg [Am]. 2001 Sep;26(5):847-54. Erratum in: J Hand Surg [Am] 2002
Jul;27(4):740.

Yalamanchi N, Klein MB, Pham HM, Longaker MT, Chang J.
Flexor tendon wound healing in vitro: lactate up-regulation of TGF-beta
expression and functional activity.
Plast Reconstr Surg. 2004 Feb;113(2):625-32.

Klein MB, Yalamanchi N, Pham H, Longaker MT, Chang J.
Flexor tendon healing in vitro: effects of TGF-beta on tendon cell collagen
production.
J Hand Surg [Am]. 2002 Jul;27(4):615-20.

Chang J, Most D, Thunder R, Mehrara B, Longaker MT, Lineaweaver WC.
Molecular studies in flexor tendon wound healing: the role of basic fibroblast
growth factor gene expression.
J Hand Surg [Am]. 1998 Nov;23(6):1052-8.

Also look at some of the work on collagen sysnthesis By Rennie's group, really good work and lot of it based on how eccentrics may increase collagen synthesis.

Miller BF, Olesen JL, Hansen M, Dossing S, Crameri RM, Welling RJ, Langberg
H, Flyvbjerg A, Kjaer M, Babraj JA, Smith K, Rennie MJ.
Coordinated collagen and muscle protein synthesis in human patella tendon and
quadriceps muscle after exercise.
J Physiol. 2005 Sep 15;567(Pt 3):1021-33. Epub 2005 Jul 7.

Babraj JA, Cuthbertson DJ, Smith K, Langberg H, Miller B, Krogsgaard MR,
Kjaer M, Rennie MJ.
Collagen synthesis in human musculoskeletal tissues and skin.
Am J Physiol Endocrinol Metab. 2005 Nov;289(5):E864-9. Epub 2005 Jun 21.

Kjaer M, Langberg H, Miller BF, Boushel R, Crameri R, Koskinen S, Heinemeier
K, Olesen JL, Dossing S, Hansen M, Pedersen SG, Rennie MJ, Magnusson P.
Metabolic activity and collagen turnover in human tendon in response to
physical activity.
J Musculoskelet Neuronal Interact. 2005 Mar;5(1):41-52. Review.

Langberg H, Ellingsgaard H, Madsen T, Jansson J, Magnusson P, Aagaard P,
Kjaer M.
Eccentric rehabilitation exercise increases peritendinous type I collagen
synthesis in humans with Achilles tendinosis.
Scand J Med Sci Sports. 2006 Jun 19;

Kjaer M, Magnusson P, Krogsgaard M, Moller JB, Olesen J, Heinemeier K,
Hansen M, Haraldsson B, Koskinen S, Esmarck B, Langberg H.
Extracellular matrix adaptation of tendon and skeletal muscle to exercise.
J Anat. 2006 Apr;208(4):445-50.

Bojsen-Moller J, Kalliokoski KK, Seppanen M, Kjaer M, Magnusson SP.
Low-intensity tensile loading increases intratendinous glucose uptake in the
Achilles tendon.
J Appl Physiol. 2006 Jul;101(1):196-201. Epub 2006 Mar 24.

Doessing S, Kjaer M.
Growth hormone and connective tissue in exercise.
Scand J Med Sci Sports. 2005 Aug;15(4):202-10. Review.

Crameri RM, Langberg H, Teisner B, Magnusson P, Schroder HD, Olesen JL,
Jensen CH, Koskinen S, Suetta C, Kjaer M.
Enhanced procollagen processing in skeletal muscle after a single bout of
eccentric loading in humans.
Matrix Biol. 2004 Jul;23(4):259-64.

Kjaer M. FANTASTIC REVIEW
Role of extracellular matrix in adaptation of tendon and skeletal muscle to
mechanical loading.
Physiol Rev. 2004 Apr;84(2):649-98. Review.
 
Please don't confuse us with science. We all know that the only true principles have come from Joe Weider anyway.
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(Old and Grey @ Jul. 12 2006,12:02)</div><div id="QUOTEHEAD">QUOTE</div><div id="QUOTE">Please don't confuse us with science. We all know that the only true principles have come from Joe Weider anyway.
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Well, you know us geeky, nerdy and some even say closest homosexual spankers who can actually bench their own weight have to keep the Deal Real, right?
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<div></div><div id="QUOTEHEAD">QUOTE</div><div id="QUOTE">Well, you know us geeky, nerdy and some even say closest homosexual spankers who can actually bench their own weight have to keep the Deal Real, right?</div>

Correction there Mr. the-other-nerd.
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I can actually bench almost 1.5 x my bodyweight, and many, many other here can too so the deal is real so much for being homosexual spankers
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Holy crap, this is just one of the funniest threads ever to come from a serious scientific question
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And I thought Dan missed that post from our &quot;friend&quot; the so-called &quot;Real Deal&quot;.
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LMAO
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By the way, my head just got bigger, I hit a new PR that I have been chasing for a while.

It was the squats (90 degree in this case) to do 2x my body weight (Bw =70 kg - Sq = 140 Kg), done today for 4 reps, could have done the fifth but got conservative, next time I should use some Ramstein just to get me going!

Yeah I know it is not olympic, I can just see Liege thrashing me for this, but yes I also do those my best there is only 90 Kg though!

Just thought I'd share some more &quot;homo&quot; lifting from the nerdy crowd!
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