Here's the thing:
Think about this logically; forget rep ranges, rep totals, blah, blah, blah...
If you are conditioned to a load it ain't gonna make you grow* whatever you do with it, whatever the reps and sets.
*(although, I suppose there may be some sort of strain effect from a very high number of reps with a load that you are conditioned to; but that number may be very high and the PS response may still be low.)
Sure it'll make you sore if you do 100 total reps instead of your usual 30 but will you grow? If you lift a can of beans 2000 times will you get sore? Yes, probably. Will you grow? Not likely, unless you are unaccustomed to lifting the weight of a can of baked beans.
As far as I am aware, there are two main routes to inducing hypertrophy (which is what HST is all about): the main one is MAPK P38 (Mitogen Activated Protein Kinase p38) and the other one is MAPK ERK 1/2 (Mitogen Activated Protein Kinase Extracellular Regulating Kinase 1 and 2). The p38 signalling pathway is induced by tension due to load and stretch; the ERK 1/2 signalling pathway is induced by metabolic work.
So, let's say you do a cycle with 15, 10, and 5 rep loads in the same week. What is going to be the effect on the muscle tissue itself?
Let's also say that at the start of the cycle you are relatively deconditioned to lighter loads; so for the first week you will be getting a decent MAPKp38 response to the tension from all three workouts. You will also be getting an ERK 1/2 response from the 15 and 10 rep workouts but very little from the 5 rep workout.
Because of RBE (repeated bout effect), the following week, the muscle tissue will be a little more resistant to the strain being applied, but the loads will be a little higher each session. Therefore, the second week may well still supply three workouts that stimulate the MAPKp38 pathway and, again, ERK 1/2 will be stimulated on the 15 and 10 rep workouts.
As the cycle progresses the effect of RBE on the first and second workouts will be more pronounced. Eventually, there will be little to no MAPK P38 pathway stimulation from the 15 and 10 rep workouts because the muscle tissue will be well conditioned to heavier loads. There will still be an ERK 1/2 effect though.
What this means is that by the end of a 15,10, 5 rep-each-week cycle, you will be missing out on the most important p38 pathway stimulation for two workouts! That's not ideal for hypertrophy.
In the end, then, what makes the most sense is to do an HST cycle as outlined in the FAQ's. Just be sure to include a higher-rep, metabolic set for each bodypart during 5s so that you also benefit from ERK 1/2 signalling during the heavy end of the cycle.
My feeling is that a lot of the critics of HST haven't really understood the underlying physiological and scientific reasons why things are laid out as they are. It's not something that Bryan thought would be fun to try! The science is sound enough to make HST a very good way to continue to maximise a hypertrophic response over a whole cycle.