Anyone tried DNP for weight loss?
- Thread starter jwjpilot
- Start date
IF you do a search on most other boards you'll fine it stands for
DNP = DO NOT PARTICIPATE.
------------------------------------
SIDE EFFECTS:
Heat- you will feel very hot while taking this. It is very similar to jogging a slow pace all day long, so be prepared to sweat a
little. In some people a lot of sweat is not too uncommon. Body temperature will rise to about 101 degrees and sustain there.
This is not too out of the ordinary. This increase in core body temperature causes a vasodilation effect throughout the body to
help cool you off. However, evaporative cooling with the aid of vasodilation will not be effective when the surrounding
environment does not allow for proper cooling. For example, being out in the summer sun when it's 90 degrees and high
humidity can cause you to rapidly overheat to dangerous levels. Avoid hot environments at all costs. Stay indoors if you
choose to use it in the summer and only go outside briefly when it's absolutely necessary. Dehydration can cause the body to
not regulate temperature properly and rapidly overheat as well. Drink 1-3 gallons of water daily depending on DNP dose.
Water retention- this is very closely associated with heat. When the vasodilation occurs due to the rise in body temperature,
blood vessels expand, causing an increase in blood volume and subsequent water retention. Also, an increased blood volume
leads to decreased pressure, which would lead the body to try to store more sodium and cause even more water retention. All
the water retention will subside within a week after stopping the DNP dosage, but often sooner than that. Popular diuretics are
not very effective against DNP induced water retention because these diuretics mainly focus on one aspect of diuresis and that
is suppression of the anti diuretic hormone (ADH), but the cause of water retention from DNP is independent of ADH. While
diuretics will get rid of some naturally stored water, it isn't getting rid of enough water that would make a competitor
presentable on stage and would put the user in jeopardy of death or serious health complications due to potassium depletion.
Lethargy- This is the biggest problem associated with DNP and is somewhat associated with the insomnia that I will cover later.
As you have learned DNP depletes the body of ATP and without ATP you have no energy. It literally feels like you're jogging
a marathon all day long without a break. Of course the extent of the lethargy will depend on the dose, but it is not uncommon
for people to be almost bed ridden. Walking to the kitchen to get food will be a chore. Even eating the food can become very
laborious. This will subside within 24-36 hours of stopping the doses.
Insomnia- sleeping will be very difficult for some people, not because of the familiar central nervous stimulation experienced
with ephedrine and caffeine supplementation, but because it gets so damned hot. Many people including myself find it very
difficult to sleep when we're sweating in our beds. The best way to combat this is to sleep with 2 fans from both sides of the
bed and the air conditioner cranked up. Obviously if you have a significant other that you sleep with then it would be wise to
sleep in separate beds for parts of the cycle.
Shortness of breath/ rapid breathing- this is common when the dose is at the upper limits. The breathing will seem like you're
jogging even while you're sitting down and doing nothing. It will seem like you can never catch your breath. Doing anything
active will make you even more out of breath and this can become dangerous. When breathing becomes irregular, you should
avoid doing any aerobic or strenuous activities. This means no working out (not like you'll have any energy to do so anyway).
Dehydration- a very serious side effect. If hydration levels are not adequate it can predispose the body to severe overheating
and possibly death. Water needs to be replenished on the order of 1-3 gallons per day.
Electrolyte depletion- this is caused by excessive water and salt loss through sweating. Drinking water will replace fluids, but
not electrolytes. Best way to replenish salts is to drink v8 juice. This can lead to a host of other problems if not remedied
including excessive lethargy, low blood pressure, poor cardiac function, nausea, diarrhea…
Nausea- This is a common side effect that afflicts roughly around 30% of the users. There could be several causes to this:
dehydration, electrolyte imbalance, low blood pH, and other unknown (by me) mechanisms.
Diarrhea- possibly due to electrolyte imbalance and undissolved DNP that passes onto the large intestine causing osmotic
imbalances. If this becomes too problematic the only thing to do is just to decrease the dosage or stop completely.
Headache- largely due to dehydration. In most people, forcing down a liter of fluids will alleviate the headaches.
Dry/ sore throat- I don't know the cause of this one, but it is pretty common among users and seems to manifest itself the most
during sleep and may contribute to the insomnia.
Allergies/ dermatitis- this is relatively rare. I've been in contact with nearly 500 people who have used DNP and I would
estimate about 30-40 of them have experienced allergic reactions to DNP. The allergies manifest themselves first as phantom
itches (itching without any rashes or redness) around the torso in some people. It will later develop into rashes and or hives
around the body and possibly spread to the face, neck, lips, and scalp area in severe cases. Any over the counter or
prescription allergy medication (anti histamine) will cure the allergies. Also if you're allergic to DNP it doesn't mean you can't
use it in the future. Allergies to DNP seem to have a tolerance factor. It first gets worse, then better with successive cycles. So
if you are allergic, stop immediately and start again 7-10 days later and repeat until you are no longer allergic to DNP anymore.
Allergies are also dose and length dependent.
Yellow vision- This is even more rare than allergies. I've only known about 15 people who have experienced this out of all the
people I have come in contact with who have used DNP in the past. It seems to be most apparent when you look at a white
surface and yellow spots will appear on the white that you see. I'm not sure what exactly causes this, but it doesn't seem to
harm anything and goes away within 1-2 days of stopping the doses.
DNP = DO NOT PARTICIPATE.
------------------------------------
SIDE EFFECTS:
Heat- you will feel very hot while taking this. It is very similar to jogging a slow pace all day long, so be prepared to sweat a
little. In some people a lot of sweat is not too uncommon. Body temperature will rise to about 101 degrees and sustain there.
This is not too out of the ordinary. This increase in core body temperature causes a vasodilation effect throughout the body to
help cool you off. However, evaporative cooling with the aid of vasodilation will not be effective when the surrounding
environment does not allow for proper cooling. For example, being out in the summer sun when it's 90 degrees and high
humidity can cause you to rapidly overheat to dangerous levels. Avoid hot environments at all costs. Stay indoors if you
choose to use it in the summer and only go outside briefly when it's absolutely necessary. Dehydration can cause the body to
not regulate temperature properly and rapidly overheat as well. Drink 1-3 gallons of water daily depending on DNP dose.
Water retention- this is very closely associated with heat. When the vasodilation occurs due to the rise in body temperature,
blood vessels expand, causing an increase in blood volume and subsequent water retention. Also, an increased blood volume
leads to decreased pressure, which would lead the body to try to store more sodium and cause even more water retention. All
the water retention will subside within a week after stopping the DNP dosage, but often sooner than that. Popular diuretics are
not very effective against DNP induced water retention because these diuretics mainly focus on one aspect of diuresis and that
is suppression of the anti diuretic hormone (ADH), but the cause of water retention from DNP is independent of ADH. While
diuretics will get rid of some naturally stored water, it isn't getting rid of enough water that would make a competitor
presentable on stage and would put the user in jeopardy of death or serious health complications due to potassium depletion.
Lethargy- This is the biggest problem associated with DNP and is somewhat associated with the insomnia that I will cover later.
As you have learned DNP depletes the body of ATP and without ATP you have no energy. It literally feels like you're jogging
a marathon all day long without a break. Of course the extent of the lethargy will depend on the dose, but it is not uncommon
for people to be almost bed ridden. Walking to the kitchen to get food will be a chore. Even eating the food can become very
laborious. This will subside within 24-36 hours of stopping the doses.
Insomnia- sleeping will be very difficult for some people, not because of the familiar central nervous stimulation experienced
with ephedrine and caffeine supplementation, but because it gets so damned hot. Many people including myself find it very
difficult to sleep when we're sweating in our beds. The best way to combat this is to sleep with 2 fans from both sides of the
bed and the air conditioner cranked up. Obviously if you have a significant other that you sleep with then it would be wise to
sleep in separate beds for parts of the cycle.
Shortness of breath/ rapid breathing- this is common when the dose is at the upper limits. The breathing will seem like you're
jogging even while you're sitting down and doing nothing. It will seem like you can never catch your breath. Doing anything
active will make you even more out of breath and this can become dangerous. When breathing becomes irregular, you should
avoid doing any aerobic or strenuous activities. This means no working out (not like you'll have any energy to do so anyway).
Dehydration- a very serious side effect. If hydration levels are not adequate it can predispose the body to severe overheating
and possibly death. Water needs to be replenished on the order of 1-3 gallons per day.
Electrolyte depletion- this is caused by excessive water and salt loss through sweating. Drinking water will replace fluids, but
not electrolytes. Best way to replenish salts is to drink v8 juice. This can lead to a host of other problems if not remedied
including excessive lethargy, low blood pressure, poor cardiac function, nausea, diarrhea…
Nausea- This is a common side effect that afflicts roughly around 30% of the users. There could be several causes to this:
dehydration, electrolyte imbalance, low blood pH, and other unknown (by me) mechanisms.
Diarrhea- possibly due to electrolyte imbalance and undissolved DNP that passes onto the large intestine causing osmotic
imbalances. If this becomes too problematic the only thing to do is just to decrease the dosage or stop completely.
Headache- largely due to dehydration. In most people, forcing down a liter of fluids will alleviate the headaches.
Dry/ sore throat- I don't know the cause of this one, but it is pretty common among users and seems to manifest itself the most
during sleep and may contribute to the insomnia.
Allergies/ dermatitis- this is relatively rare. I've been in contact with nearly 500 people who have used DNP and I would
estimate about 30-40 of them have experienced allergic reactions to DNP. The allergies manifest themselves first as phantom
itches (itching without any rashes or redness) around the torso in some people. It will later develop into rashes and or hives
around the body and possibly spread to the face, neck, lips, and scalp area in severe cases. Any over the counter or
prescription allergy medication (anti histamine) will cure the allergies. Also if you're allergic to DNP it doesn't mean you can't
use it in the future. Allergies to DNP seem to have a tolerance factor. It first gets worse, then better with successive cycles. So
if you are allergic, stop immediately and start again 7-10 days later and repeat until you are no longer allergic to DNP anymore.
Allergies are also dose and length dependent.
Yellow vision- This is even more rare than allergies. I've only known about 15 people who have experienced this out of all the
people I have come in contact with who have used DNP in the past. It seems to be most apparent when you look at a white
surface and yellow spots will appear on the white that you see. I'm not sure what exactly causes this, but it doesn't seem to
harm anything and goes away within 1-2 days of stopping the doses.
WOW Mikeh,
Thanks for all the information, it's wonderful!
Do you know of any people that have died from DNP?
Or serious complications that did not reduce after stopping use?
Would you recommend it's use, or do you feel the dangers outweigh the weight loss?
From my standpoint it looks pretty darn dangerous.
JWJ
Thanks for all the information, it's wonderful!
Do you know of any people that have died from DNP?
Or serious complications that did not reduce after stopping use?
Would you recommend it's use, or do you feel the dangers outweigh the weight loss?
From my standpoint it looks pretty darn dangerous.
JWJ
I
imported_imbgrad
Guest
I think I learned about this stuff in my undergrad metabolism class. DNP is an "uncoupler" that, basically, throws your ATP synthesis machinery into neutral while the engine is floored. I think these agents were used as diet drugs in the 30s but caused major problems, as described above. I think it is also lipophilic and tends to collect in the brain, where you absolutely do not want to loose ATP manufacturing ability!
There is no doubt it is an effective diet agent. But geeze.. scary stuff.
I just googled it and I was amazed to see it for sale online! In fact, I remember we used it as a reagent in organic chemistry and were told to be very, very careful with it. Bright orange stuff.
Here's a fun list of things you can do to shut down your mitochondria, DNP stuff is on here.
http://www.ruf.rice.edu/~biosla....ns.html
To quote:
"Back in the 1930s DNP was touted as an effective diet pill. Indeed, the uncoupling of electron transport from ATP synthesis allows rapid oxidation of Krebs substrates, promoting the mobilization of carbohydrates and fats, since regulatory pathways are programmed to maintain concentrations of those substrates at set levels. Since the energy is lost as heat, biosynthesis is not promoted, and weight loss is dramatic. However, to quote Efraim Racker (A New Look at Mechanisms in Bioenergetics, Academic Press, 1976, p. 155), ..."the treatment eliminated not only the fat but also the patients,...This discouraged physicians for awhile..."
It is not a good idea to mess with cellular metabolism."
There is no doubt it is an effective diet agent. But geeze.. scary stuff.
I just googled it and I was amazed to see it for sale online! In fact, I remember we used it as a reagent in organic chemistry and were told to be very, very careful with it. Bright orange stuff.
Here's a fun list of things you can do to shut down your mitochondria, DNP stuff is on here.
http://www.ruf.rice.edu/~biosla....ns.html
To quote:
"Back in the 1930s DNP was touted as an effective diet pill. Indeed, the uncoupling of electron transport from ATP synthesis allows rapid oxidation of Krebs substrates, promoting the mobilization of carbohydrates and fats, since regulatory pathways are programmed to maintain concentrations of those substrates at set levels. Since the energy is lost as heat, biosynthesis is not promoted, and weight loss is dramatic. However, to quote Efraim Racker (A New Look at Mechanisms in Bioenergetics, Academic Press, 1976, p. 155), ..."the treatment eliminated not only the fat but also the patients,...This discouraged physicians for awhile..."
It is not a good idea to mess with cellular metabolism."