coach hale
New Member
Insulin is often referred to as the most important anabolic hormone, interestingly this may not be the case. It appears that insulin does not have the same affects in adult humans as it does in growing animals that are often used for research. Alan Aragon does an excellent job of addressing this subject in the curent edition of AARR. He points out that the positive effects of insulin on protein balance are due to it's ability to inhibit protein breakdown. How much insulin is needed to prevent breakdown? Very little 15-30 mU/L, which is barely over fasted levels, which are generally 5-10 mU/L . In reality, a small-moderate mixed meal, or small carb prot shake will suffice. When administering glucose tolerance tests insulin levels of up to slightly less than 80 mU/L are considered normal at the one hour mark. From this we can extrapolate little food is required to reach insulin levels of 15-30 mU/L.
Research Says
Bell demonstrated that systemic infusion of insulin and energy, without the infusion of AA, didn't increase MPS
Fujita found the hyperinsulinemia only stimulates and increase in MPS when accompanied by elevated AA delivery
Indispensable amino acid availability is the primary factor driving protein synthesis, although insulin and energy may modulate the response
Cuthbertson et. al. 2004, found it appears be possible to stimulate muscle protein synthesis by supplying exogenous amino acids alone while maintaining basal blood insulin concentration at the overnight fasted level
Greenhaff et. .al 2005, reported if amino acids in amounts capable of producing a maximal response in protein synthesis are ingested, adding further insulin has no further stimulatory effect on PS
Rennie 2005, reports muscle protein synthesis is also independent of increases in GH or IGF-1
thanks,
Coach Hale
www.maxcondition.com
Research Says
Bell demonstrated that systemic infusion of insulin and energy, without the infusion of AA, didn't increase MPS
Fujita found the hyperinsulinemia only stimulates and increase in MPS when accompanied by elevated AA delivery
Indispensable amino acid availability is the primary factor driving protein synthesis, although insulin and energy may modulate the response
Cuthbertson et. al. 2004, found it appears be possible to stimulate muscle protein synthesis by supplying exogenous amino acids alone while maintaining basal blood insulin concentration at the overnight fasted level
Greenhaff et. .al 2005, reported if amino acids in amounts capable of producing a maximal response in protein synthesis are ingested, adding further insulin has no further stimulatory effect on PS
Rennie 2005, reports muscle protein synthesis is also independent of increases in GH or IGF-1
thanks,
Coach Hale
www.maxcondition.com