If you are a very strong and experienced lifter for your size & weight, then the first option will likely work better for hypertrophy. If you aren't, then both options will probably yield similar results—although gauging effective volume for a 2RM w/o might be tricky. Why not try: 15, 12, 9, 6, 3?
Stronger people will put a lot more stress on their CNS if they spend more sessions, during a cycle, working at a higher %age of their 1RM (ie. at a higher intensity).