feeding frequency on insulin and ghrelin responses

dkm1987

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Br J Nutr. 2008 Apr 8;:1-10

The effect of feeding frequency on insulin and ghrelin responses in human subjects.

Solomon TP, Chambers ES, Jeukendrup AE, Toogood AA, Blannin AK.


Recent work shows that increased meal frequency reduces ghrelin responses in sheep. Human research suggests there is an interaction between insulin and ghrelin. The effect of meal frequency on this interaction is unknown. Therefore, we investigated the effect of feeding frequency on insulin and ghrelin responses in human subjects. Five healthy male volunteers were recruited from the general population: age 24 (sem 2) years, body mass 75.7 (sem 3.2) kg and BMI 23.8 (sem 0.8) kg/m2. Volunteers underwent three 8-h feeding regimens: fasting (FAST); low-frequency (two) meal ingestion (LOFREQMEAL); high-frequency (twelve) meal ingestion (HIFREQMEAL). Meals were equi-energetic within trials, consisting of 64 % carbohydrate, 23 % fat and 13 % protein. Total energy intake was equal between feeding trials. Total area under the curve for serum insulin and plasma ghrelin responses did not differ between trials (P>0.05), although the hormonal response patterns to the two meal feeding regimens were different. An inverse relationship was found between serum insulin and plasma ghrelin during the FAST and LOFREQMEAL trials (P 0.05). This study provides further evidence that the postprandial fall in ghrelin might be due, at least partially, to the rise in insulin and that high-frequency feeding may disrupt this relationship.
 
If there is a negative relationship between insulin and ghrelin, does that mean that lowcarb dieting promotes GH-production?
Also, twelve feedings daily would mean that insulin is quite stable since there is an almost constant stream of nutrients, wouldn't it? So, is it safe to say that drastic changes in insulin levels are what is causing the drop in ghrelin, and thus is bad for GH?
 
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(Minime @ Apr. 29 2008,2:48)</div><div id="QUOTEHEAD">QUOTE</div><div id="QUOTE">If there is a negative relationship between insulin and ghrelin, does that mean that lowcarb dieting promotes GH-production?</div>
Not neccessarily. A study looking specifically into GH response on a low carb diet did not show this. The diet was only 5% carb, High fat and moderate protein. I can't remember the exact fat and protein % though but I'm sure I have the full text version somewhere (if I had to look it up again). Anyway even though insulin AUC dropped by something like 50% during the 7 day LC diet, GH remained about the same (pulse freq and pulse magnitude).
 
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