Nitric Oxide

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Papillon

New Member
Howdy all!!
My buddy has been raving about these nitric oxide pills so I decided to give them a try. They are mostly L-Arginine Alpha Keto-Glutarate (3000 mg). I have to admit that I have noticed an increase in vascularity and the feeling of a "full body pump."
I was just wondering if anyone had any experience or comments about this supplement. Dangerous? Complete waste of time? etc...
BTW I am impressed with HST. I have had great results with it and this is always the 1st website I hit when i pop online. Thanks much and keep up the good work.

P
 
Eh, I'm sure you will get mixed replies. Some say that the pump is placebo or whatever. However, I have read some credible research as to the positive health effects of NO not related to lifting. I took it and noticed little difference, especially for the price. I might consider just L-Arginine...
 
I have heard on some messageboards that NO can be dangerous, but I've never bothered to look into why they claim it to be. Although I don't think feeling a pump from it will actually help your progress with regards to hypertrophy.
 
Hello all!  :)

Well, the science beyond NO is impressive, however I myself still can't vouch for its effectiveness, nor can I say it's trash. I studied it for a while, but haven't really tried it. I try to take only as little supplements as I can, saves me a lot of cash  
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Anyhoo, NO is generated by the body naturally through the amino acid Arginine. Now, I believe some people claim that other ingredients of theirs also produce NO, but that's just garbage. Only Arginine produces NO, period. And Arginine Alpha-Ketoglutarate (AAKG) is the best analog to Arginine. Any other ingredient that people (especially supplement companies) claim to produce NO is simply crap, because the body still needs to convert those to Arginine first before it can produce NO.

Now, even if you swallow a bucket full of pure Arginine, you won't gain an ounce of muscle. This is because the Arginine has to reach the target site. Here is where those NO supplements come in: they boast that their delivery systems are specifically designed to make sure the Arginine (and thus the NO production which you could use) reaches its target site. Or rather, AAKG, not just pure Arginine. For scientific reasons we don't have to cover here, AAKG is better in this regard than just pure Arginine.

On we go... the real power behind nitric oxide is the "scientific" claim that the NO molecules produced somehow activates satellite cells in the muslces, therefore growing new muscle fiber. Now, we all know that generally, we don't really create new fibers (which is hyperplasia), we just make our existing fibers much larger (which is hypertrophy). In the long run, however (or so says the facts of science right now), hyperplasia does seem to set in, so yes, it is a fact that it happens. But NO is like hyperplasia in steroids - it happens almost immediately with the NO, which is why they claim NO gives you incredible gains --> you workout, you enlrage your existing fibers (hypertrophy) and also create new fibers (hyperplasia).

That's all the science I know, and I hope that helps.  :)
- JV
 
To my understanding, NO supplementation is not trying to achieve increased satellite cell activation, but instead to increase delivery of nutrients to cells via hemodilation. And I have not read even one study that has ever related arginine supplementation to hyperplasia, or even hypertrophy for that matter. True some people claim it is good for a pump, but so what? If a pump is what you are after, just eat more carbs. JMO, NO supps are junk.
 
Id' agree with Baby A, it still seems like a waste of money. Probably some marketing crap.

But then again, that's the problem. Because of the cacophony of "evil companies" trying to market their substandard products with wild claims, sometimes really useful stuff also gets branded as junk. That's a waste, considering creatine was also introduced through marketing so many years ago which is how it got popular, and turns out it isn't just junk. It could be the same thing with NO, but we just don't know yet.

And yes, NO causes dilation of blood vessels called hemodilation, just like how Viagra works. However, some research, particularly by the Medical Research Institute (MRI), tend also to attribute the muscle gains they claim is associated with NO as due to satellite cell activity. When you workout, satellite cells repair the damage muscles and they become larger (again, hypertrophy), but MRI is also speculating (I don't know the level of proof they have, if at all) that it isn't just hypertrophy that happens, that in fact the satellite cells also become new fiber (hyperplasia) due to NO (they say that NO must somehow 'activate' the satellite cells into not just repairing muscle fiber but also becoming new fiber themselves).

Like I said, I personally don't take it, and right now, based on research currently available that I know about, I wouldn't advise anybody yet to use it. Just my two cents. :)

- JV
 
[b said:
Quote[/b] (jvroig @ July 22 2005,5:48)]And yes, NO causes dilation of blood vessels called hemodilation, just like how Viagra works. However, some research, particularly by the Medical Research Institute (MRI), tend also to attribute the muscle gains they claim is associated with NO as due to satellite cell activity. When you workout, satellite cells repair the damage muscles and they become larger (again, hypertrophy), but MRI is also speculating (I don't know the level of proof they have, if at all) that it isn't just hypertrophy that happens, that in fact the satellite cells also become new fiber (hyperplasia) due to NO (they say that NO must somehow 'activate' the satellite cells into not just repairing muscle fiber but also becoming new fiber themselves).
Click to expand...
MRI (Medical Research Institute) is a sham company founded by Ed Byrd, who is also the NO "guru" who first introduced NO2. Of course he is going to make all kinds of outrageous claims about his supplements, and any "tests" he performed showing it to be useful for hyperplasia or hypertrophy are far from being authentic.
 
Thanks for the info..
I think I'll go off of it for a month or so and see how I feel. I know my girlfriend wont mind. Poor girl hasnt gotten much sleep since I started taking them hehehehehehe.

P
 
[b said:
Quote[/b] ]MRI (Medical Research Institute) is a sham company founded by Ed Byrd, who is also the NO "guru" who first introduced NO2. Of course he is going to make all kinds of outrageous claims about his supplements, and any "tests" he performed showing it to be useful for hyperplasia or hypertrophy are far from being authentic.
Click to expand...

Really? Wow. I said there I didn't know what level of proof they have, and it did seem kinda doubtful to me. I have to admit you are probably right about MRI. They must be one of those "evil companies" I mentioned. Thanks for the info, baby_a

Well, hopefully more valid scientific research (i.e., those without vested interests) will turn up soon.
 
Actually it's already out there, the role of the NO in many functions are important. In resistance training the effects are noted as wound repair, inflammation and others. Is it necessary to supplement? doubtful.

Arginine, the miracle amino acid :D Let's see it increases GH release, NOT, it helps with immunity, MAYBE, if you are deficient and ill, it cures Autoimmune Deficiency, YEAH RIGHT, oh yeah it builds huge huge huge muscles, err ummmm OK sure
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Wow, so it's OK for some health reasons, but not really much (or at all) for bodybuilding.
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There you go.

Hehehe, well, back to studying bodybuilding lore again, I guess!
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-JV
 
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