Oligopeptides for Fat Loss?

Discussion in 'Anything and Everything about dietary supplements' started by Jon Stark, Jul 9, 2002.

  1. Jon Stark

    Jon Stark New Member

    I've been seeing some products lately (particular from Sportpharma) containing oligopeptides that purportedly have fat-fighting properties.

    Is there any empirical evidence (or even theoretical basis) for believing this stuff might be effective?

    Will Brink mentioned oligopeptides on his site.  Here's his summary of the (non-peer reviewed) research.

    Study #1: "Oligopeptides suppress fat deposition and influence on the cellularity of adipose tissue." (Kagawa, et al) This research did not come from a journal but was given to me by a researcher friend who wanted my opinion on the stuff. This is "in house" research done by a Japanese pharmaceutical company. The product is called Peptide FM and it appears to have some very interesting properties. Peptide FM is made from various proteins with specific amino acid sequences. The proteins are fractioned to get specific peptides with certain amino acid sequences of a certain length. Peptide FM appears to be able to reduce fat deposition from both the intake of fat and carbohydrates in the diet. It has effects at both the digestive and cellular level and has been shown to inhibit lipogenesis (fat storage) in both liver and adipose tissue. Peptide FM was shown to inhibit certain enzy mes involved with the production and subsequent storage of fat in fat cells and increases beta-oxidation (fat burning) in several animal models. Peptide FM was also shown to reduce triglycerides in this research. Just as important as its effects, it was found to do all this at very small doses.

    Now for the bad news. So far, very little of this research has been published in peer reviewed journals and all of the research has been done by the same group. It is hard to tell just how good this stuff is until it goes through some confirmation by other researchers. Companies involved in making these types of products are sort of stuck between a rock and a hard place. If they publish their material right away someone might steal the idea from them and if they sit on it "in house" it looks as if they are trying to hide something. So will this be the best thing for bodybuilders since the squat rack? It's to early to tell but I would expect to see this stuff pop up in various products in the coming months.

    (I got this here: http://www.brinkzone.com/scinutrition.html)
  2. virtualcyber

    virtualcyber New Member


    I looked up the article -- pretty interesting. Too bad relevant information is "hidden." When the article goes on at length about sequences of peptides, but does not explain the mechanism by which fat deposition and lipogenesis is prevented, I get the feeling that the whole thing is like "black magic."

    But ... Are you going to try the stuff? [​IMG]
  3. Jon Stark

    Jon Stark New Member

    I tried Methoxy-7. And that Russian Bear crap that was always advertised on the back cover of Muscular Development.

    So why the hell not?

    (I'm kidding about the Russian Bear stuff.)

    If I do try it, I'll provide a full report. I'm doing CLA now, so to give oligopeptides a fair shake I should wait until I'm not using any other fat loss supplements.
  4. virtualcyber

    virtualcyber New Member

    Jon, Was the product called Pepti-Lean, by SportPharma?

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