Skeletal Muscle Hypertrophy after Chronic Restriction of Venous Blood Flow in Rats.
Medicine & Science in Sports & Exercise. 37(7):1144-1150, July 2005.
KAWADA, SHIGEO 1; ISHII, NAOKATA 2
Abstract:
Purpose: Some previous studies have shown that resistance exercise training with venous occlusion causes an enhanced hypertrophy in human muscles. To investigate the effects of blood flow on muscular size at either cellular or subcellular level, we developed an animal model in which several veins from hindlimb muscles of the rat are surgically crush-occluded.
Methods: Twenty-four male Wister rats were randomly assigned into either a group for sham operation (sham group) or a group for venous occlusion (experimental group; N = 12 for each group). Fourteen days after the operation, plantaris, soleus, gastrocnemius, extensor digitorum longus, and tibialis anterior muscles were dissected from hindlimbs and subjected to morphological and biochemical analyses.
Results: Fourteen days after the operation, the muscles expect for soleus showed similar increases in wet weight/body weight (by 7-12%) as compared with the sham-operated group (P < 0.05). Further analyses on the plantaris muscle showed increases in muscle dry weight/ body weight (by 10%) and the concentrations of myofibrillar protein (by 23%), glycogen (by 93%) and lactate (by 23%) after the operation (P < 0.05). Mean fiber cross-sectional area was larger by 34% in the experimental group than in the sham-operated group (P < 0.01). The content of HSP-72 increased, whereas that of myostatin protein decreased (P < 0.01). The expression of nitric oxide synthase-1 (NOS-1) mRNA increased (P < 0.01), whereas that of IGF-1 mRNA showed no significant change (P = 0.36). Although the muscle nitric oxide (NO) concentration tended to increase, but the change was not significant (P = 0.10).
Conclusions: Changes in muscle blood flow may affect the muscular size through actions of HSP-72, myostatin, and NOS-1.
©2005The American College of Sports Medicine
http://www.ms-se.com/pt....!-1
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Increase in glycogen storage are HUGE
It seems that restrictions of blood flow lead to superior hypertrophy. How can it be compared to classical weight training ? Is it possible to emulate blood flow restriction with "pumping sets" or short rest between sets ?
So far my experiences with high rep sets (20+) didn't make me grow despite the pump/burn.
BTW Super Slow is generaly not a good way to build muscles mass but it would be a good way to emulate the occlusion studies, isn't it ?
Medicine & Science in Sports & Exercise. 37(7):1144-1150, July 2005.
KAWADA, SHIGEO 1; ISHII, NAOKATA 2
Abstract:
Purpose: Some previous studies have shown that resistance exercise training with venous occlusion causes an enhanced hypertrophy in human muscles. To investigate the effects of blood flow on muscular size at either cellular or subcellular level, we developed an animal model in which several veins from hindlimb muscles of the rat are surgically crush-occluded.
Methods: Twenty-four male Wister rats were randomly assigned into either a group for sham operation (sham group) or a group for venous occlusion (experimental group; N = 12 for each group). Fourteen days after the operation, plantaris, soleus, gastrocnemius, extensor digitorum longus, and tibialis anterior muscles were dissected from hindlimbs and subjected to morphological and biochemical analyses.
Results: Fourteen days after the operation, the muscles expect for soleus showed similar increases in wet weight/body weight (by 7-12%) as compared with the sham-operated group (P < 0.05). Further analyses on the plantaris muscle showed increases in muscle dry weight/ body weight (by 10%) and the concentrations of myofibrillar protein (by 23%), glycogen (by 93%) and lactate (by 23%) after the operation (P < 0.05). Mean fiber cross-sectional area was larger by 34% in the experimental group than in the sham-operated group (P < 0.01). The content of HSP-72 increased, whereas that of myostatin protein decreased (P < 0.01). The expression of nitric oxide synthase-1 (NOS-1) mRNA increased (P < 0.01), whereas that of IGF-1 mRNA showed no significant change (P = 0.36). Although the muscle nitric oxide (NO) concentration tended to increase, but the change was not significant (P = 0.10).
Conclusions: Changes in muscle blood flow may affect the muscular size through actions of HSP-72, myostatin, and NOS-1.
©2005The American College of Sports Medicine
http://www.ms-se.com/pt....!-1
-
Increase in glycogen storage are HUGE
So far my experiences with high rep sets (20+) didn't make me grow despite the pump/burn.
BTW Super Slow is generaly not a good way to build muscles mass but it would be a good way to emulate the occlusion studies, isn't it ?
