NWlifter
Active Member
Thanks DKM, That's the one!
I'm going to re-quote Bryan here for everyone
I'm going to re-quote Bryan here for everyone
[b said:Quote[/b] ]I myself have written about it when elaborating on Siff and Verkhoshansky's work. However, I did not present any info to support or refute it...I was simply passing on concepts then current in respected strength training camps.
However, today, several years after having written about the topic, there is evidence that "irrational hypertrophy" or the pathological increase in sarcoplasm relative to contractile proteins, is a false concept.
For one, there is a fixed nuclear to sarcoplasmic ratio...meaning, the muscle cell can't increase its volume without increasing its number of nuclei. Why? Because the nuclei are required to produce contractile and cytoskeletal proteins in proportion to the increase in volume. If you prevent new nuclei from being added to muscle cells they simply won’t grow.
We now have a newer model explaining the sometimes-observed imbalances in muscle size and function. If you recall, researchers are now showing that rather than imbalances in sarcoplasm, muscle function is determined by the cells oxidative capacity which is determined largely by the frequency with which it is flooded with metabolic by products etc. (M. J. Rennie. How muscles know how to adapt J. Physiol., August 15, 2001; 535(1): 1 – 1 and related articles in same issue) Just another example of the S.A.I.D. principle involving enzymes etc. Not a structural issue.