Search results

Actually, there is a pretty big difference between pseudoephedrine and ephedrine. Pseudoephedrine has higher affinity for alpha adrenergic receptors, and low affinity for beta receptors. Ephedrine has high affinity for beta receptors, and most important the beta-2 receptor. This difference...

Salbutamol/albuterol/ventolin is a short acting beta-2 agonist. Its effects are similar to clenbuterol, but it has a rapid onset of action and only lasts for about 3-4 hours. Yes, it probably will increase your RMR for 3-4 hours after you use it, and I understand these types of stimulants...

Steroids are known to be very stable. If they aren't in solution, in a sealed dry container...who knows? Certainly you could keep them for several years. Putting them in the freezer would most likely lengthen the time you could store them as well.

FYI, here are the substances listed on the Biden bill. Sorry, some of the greek symbols didn't work, but I think you'll get the idea. It covers just about everything on the market at the moment. ‘‘(A) The term ‘anabolic steroid’ means any drug or 10 hormonal substance, chemically and...

Here is a question I always wondered about. When you are talking maintenance calories relative to bodyweight, is that lean body mass or total body weight?

It thought synephrine was more of an alpha agonist, and only hit the beta receptors mildly if at all. You wouldn't want that, since the alpha adrenergic receptors cause most of the unwanted side effects, and the beta (esp. beta-3) receptors are responsible for fat burning. Also, synephrine in a...

Yohimbine is an a2 ANTagonist, not agonist (you wouldn't want that anyway). By blocking the a2 inhibitory receptors on fat cells, it can potentiate (but not cause) lipolysis. That is why many fat burning supplements contain combinations of E with Y. It does this minimizing its effects on the a2...

I have been wondering about aromatase inhibitors and SHBG suppression for a while, and did some checking of the literature. It appears that a link between aromatase inhibitors and decreased SHBG is somewhat inconclusive. I found four "relatively" (nothing found newer than '02) recent...

The doses were given at the start of the training session. Below is taken directly from the methods section (p. E553) of the paper: T. A. TRAPPE, et al. Am J Physiol Endocrinol Metab 282: E551-E556, 2002. Drug dose and administration. Drugs were administered in a double-blind...

One more thing that should also be kept in mind about generalizing the results of this study, is that the authors didn't examine timing of the doses in relation to protein synthesis. An interesting note about inflammation and healing in general (muscle or otherwise) is that if inflammation is...

I have heard of people injecting prostaglandins for local muscle growth, but not heard of ingesting the precursor. Can't say if it will work or not. I can imagine all sorts of side effects though. Speaking from an immunological standpoint anyway. Arachidonic acid is an n-6 polyunsaturated fatty...

Yes, there are a number of papers dealing with glycation of histones. Histones, as you probably know, are proteins with which chromosomal DNA associates that help pack the DNA into chromatin. I assume what this paper is saying is that glycation of histones can modulate how a histone associates...

In the paper the author does directly address glycation of nucleic acid and merely says that the attachment of a sugar to a DNA strand has never been seen, and as I said before probably because the adducted nucleic acid is removed and replaced very quickly. It seems were are arguing the same...

I did some digging and found a recent review article, which hypothesizes glycation may occur in DNA.  However, the author also acknowledges that there is no evidence that glycated DNA occurs in any animal, and that if it does, it is not cumulative and it is quickly repaired (i.e...

Hmm, it doesn't work for glycation? From what I understand about basic DNA repair, any adduct (foreign molecule) that can interrupt transcription (as a bulky sugar molecule would) would be detected, excisized and repaired. If it can't, the cell most likely would go through programmed cell death...

I stand corrected.  Yes, glycation is non-enzymatic, glycosylation is.  I have been using the term glycosylation inappropriately all this time (I hate it when that happens). Anyway, about the DNA glycation theory.  I can't say that I have heard of that particular one, and a quick scan of Pubmed...

This may sound like a strange question, but how does Yohimburn smell? Maybe you oldtimers know what I am talking about. I bought some Yo-Be-Lean some years ago and it smelled so girly, I couldn't use it without people commenting how "pretty" I smelled. I still have it in my cupboard...

I think what you mean here is "glycosylation".  And yes, lots of things get glycosylated when there is a ton of glucose floating around unused in the body.  Actually, one of the worst effects of glycosylation is the thickening of basement membrane in the capillary beds of various...