[b said:
Quote[/b] (Aaron_F @ Dec. 15 2003,6:12)]
[b said:
Quote[/b] (Cliner9er @ Dec. 16 2003,2:29)]I believe a good chunk of this work was with very large dosages taken right after training.
Actually, this group didnt use large doses, just the maximum recommended otc daily doses. in particular Ibuprofen they gave a 400mg dose at 8am, trained, tehn repeated the doses so they took 1.2g/day obviously with the 4th dose at the next 8am.
Nothing huge by any sense, adn they seem to be the main group who ahve looked at it in any real depth (same study spawned several papers)
Hmm. This is the only work I have really ever seen. Without reading the study the abstract reads like they gave full OTC dosages post-training.
Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis.
Trappe TA, White F, Lambert CP, Cesar D, Hellerstein M, Evans WJ.
Donald W. Reynolds Center on Aging, Department of Geriatrics, University of Arkansas for Medical Sciences, and the Central Arkansas Veterans HealthCare System, Little Rock, Arkansas 72205, USA.
[email protected]
We examined the effect of two commonly consumed over-the-counter analgesics, ibuprofen and acetaminophen, on muscle protein synthesis and soreness after high-intensity eccentric resistance exercise. Twenty-four males (25 +/- 3 yr, 180 +/- 6 cm, 81 +/- 6 kg, and 17 +/- 8% body fat) were assigned to one of three groups that received either the maximal over-the-counter dose of ibuprofen (IBU; 1,200 mg/day), acetaminophen (ACET; 4,000 mg/day), or a placebo (PLA) after 10-14 sets of 10 eccentric repetitions at 120% of concentric one-repetition maximum with the knee extensors. Postexercise (24 h) skeletal muscle fractional synthesis rate (FSR) was increased 76 +/- 19% (P < 0.05) in PLA (0.058 +/- 0.012%/h) and was unchanged (P > 0.05) in IBU (35 +/- 21%; 0.021 +/- 0.014%/h) and ACET (22 +/- 23%; 0.010 +/- 0.019%/h). Neither drug had any influence on whole body protein breakdown, as measured by rate of phenylalanine appearance, on serum creatine kinase, or on rating of perceived muscle soreness compared with PLA. These results suggest that over-the-counter doses of both ibuprofen and acetaminophen suppress the protein synthesis response in skeletal muscle after eccentric resistance exercise. Thus these two analgesics may work through a common mechanism to influence protein metabolism in skeletal muscle.