Coming soon I'm sure

Discussion in 'Hypertrophy Research' started by dkm1987, May 23, 2010.

  1. dkm1987

    dkm1987 New Member

    J Biomed Biotechnol. 2010;2010:862591. Epub 2010 Mar 15.
    Enhanced muscle growth by plasmid-mediated delivery of myostatin propeptide.

    Hu S, Chen C, Sheng J, Sun Y, Cao X, Qiao J.
    College of Animal Science and Technology, Shihezi University, Shihezi 832002, China.

    Myostatin is a member of the transforming growth factor beta (TGF-beta) superfamily that functions as a negative regulator of skeletal muscle development and growth. Myostatin blockade therefore offers a strategy for promoting muscle growth in livestock production without resorting to genetic manipulation. In this report, we examined the effect of myostatin inhibition by plasmid-mediated delivery of a mutant myostatin propeptide (MProD76A), a natural inhibitor of myostatin, on the growth performance of mice. A significant increase in skeletal muscle mass was observed after a single intramuscular injection of naked plasmid DNA encoding MProD76A into mice. Enhanced muscle growth occurred because of myofiber hypertrophy, but no cardiac muscle hypertrophy and organomegaly was observed in the mice after myostatin inhibition by plasmid-mediated MProD76A delivery. These results demonstrate a promising approach to enhancing muscle growth that warrants further investigation in domestic animals.

    Last edited by a moderator: May 23, 2010
  2. Lol

    Lol Super Moderator Staff Member

    Yeah. I wonder who will be first to try this before climbing onto an IFBB stage?

Share This Page