Contractile element synthesis

[QuantumPositron]

For Bryan, Dan, and the like:

Is it known how a contractile elements are constructed and added to a working muscle fiber? Us bodybuilders talk about protein synthesis, but is that the same as contractile element synthesis when we talk about muscle cells? Once the proteins are made in the ribosomes...how do they get to be contractile elements?

 

[NWlifter]

You'll see a lot of times mentioned in texts and studies "MPS", which is mixed protein synthesis. So I guess we're being kinda laxed when we assume a higher protein synthesis always means more contractile growth. There are many proteins synthesized with the muscle cells, the two major ones we always consider are myofibrilliar and sarcoplasmic but others are also synthesized for cellular growth and repair. It makes it tricky unless they actually analyze the proteins being released into the cell, as to what exactly the target of the risen levels of MPS are for.

 

[dkm1987]

Ron is exactly right and I hit upon this in the Sarcoplasmic versus Myofibrillar Hypertrophy and Rep Range article that was published in Think muscle.

Once the polypeptide chain is formed (after the binding of the various aminos) . The polypeptide chain then folds and is released. The new polypeptide then will become a part of either a new myocyte complex such as the premyofibrillar lattice or a new actin, myosyn or other structural protein in the case of de novo synthesis. This is acheive via polypeptide binding sites within the cells and the affintiy of the sites will dictate which polypeptides are able to bind at the site. The complex is pretty the same when replacing damaged or degraded protein as well except the additional steps needed to dismantle the old protein structure.

 

[QuantumPositron]

Thanks both of you. I'll reread the article in ThinkMuscle.