It really depends on the how advanced you are in training, your training age and your chronological age. Once you get into Myo Reps, there is no "one size fits all". For me it works best with using Myo reps every workout for 3-4 sets per body part (i.e., one 20+ rep activation set and followed by 2-3 sets using Myo reps of 5-10 reps) 3 times per week and now incorporating Blood Flow Restriction training into legs and biceps with nice success. On some body parts, such as triceps, I also incorporate giant sets doing just one giant set Myo style using 3-4 different exercises. Sounds weird but that is what works best for me right now. I do no sets of just 15, 10 or especially 5 reps, rest and repeat. That just does not work for me with 60 years of training. My muscles need to be pushed to the max pump possible but not with weights that are heavy enough that a slight lax in form could potentially cause injury. You can't gain if you cannot train!