virtualcyber
New Member
Hi, Lyle
Sorry for clubbing this dead horse to pulp, but ... just one last time.
It seems that if one takes 1 g of glucosamine sulfate orally, about 11% fails to be absorbed by the digestive tract, 45% is metabolized by the liver, and the remaining 44% appears in the blood stream. So, I'd guess that 44% is bioavailable for use by the body.
I know you felt that glucosamine had relatively poor oral delivery and poor bioavailability ... but would it be possible that the above absorption rate be good enough to raise blood leptin levels?
For rats, it seems that 1 mmol/ml was the amount used to raise leptin. I have no clue how much glucosamine sulfate that translates to, for humans, given the above absorption rate.
============================================
Reference:
"Absorption, distribution, metabolism and excretion of glucosamine sulfate. A review."
by Setnikar I, Rovati LC.
Sorry for clubbing this dead horse to pulp, but ... just one last time.
It seems that if one takes 1 g of glucosamine sulfate orally, about 11% fails to be absorbed by the digestive tract, 45% is metabolized by the liver, and the remaining 44% appears in the blood stream. So, I'd guess that 44% is bioavailable for use by the body.
I know you felt that glucosamine had relatively poor oral delivery and poor bioavailability ... but would it be possible that the above absorption rate be good enough to raise blood leptin levels?
For rats, it seems that 1 mmol/ml was the amount used to raise leptin. I have no clue how much glucosamine sulfate that translates to, for humans, given the above absorption rate.
============================================
Reference:
"Absorption, distribution, metabolism and excretion of glucosamine sulfate. A review."
by Setnikar I, Rovati LC.