When a muscle has been hypertrophied and is then allowed to atrophy, what, if any, are the mechanisms by which hypertrophy is able to reoccur at a faster rate than originally? ie. what really is Muscle Memory in the context of muscle hypertrophy? When I searched for an answer I came across this article by Bryan (of all people!) which goes some way to explaining the phenomenon, but the article has to be a few years old as it was part of the second Think Muscle newsletter. Can anything now be added to this to confirm the ideas Bryan mentioned in the article? Muscle Memory: Scientists May Have Unwittingly Uncovered Its Mystery I am sure some of you will have read that before but I hadn't. In view of what is said there, would it not be the case that lean muscle mass lost during a cut would be more readily regained (than when the muscles were originally hypertrophied) and therefore lead to an improved P-ratio? ie. you'd gain back lost lean mass with a comparably lower increase in fat. Thoughts? Studies?