New study on creatine show more benefits

Discussion in 'Hypertrophy Research' started by abanger, Nov 22, 2009.

  1. abanger

    abanger Member

    Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation.
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    (Borge Fagerli @ Nov. 2 2007,11:48)</div><div id="QUOTEHEAD">QUOTE</div><div id="QUOTE">A new study of creatine has really taken up most of the mechanisms of muscle growth, and shows a dramatic effect on all genes and neurotransmitters involved in muscle growth. Creatine pull fluid into the muscle cell, and partly through increased osmotic pressure is put into motion a whole cascade of processes that activate dormant satellite cells (which can merge with the muscle cells and increase the potential for future muscle growth), increase protein and glycogen content, rest and repair of the integrity of the cells.

    In this study it was used a so-called charging phase of 20g per day for 3 days followed by 5g per day for 7 days. However, it is possible to use only the dose of 5g per day - after about 20 days you will still have full stock of creatine in the muscles. You can read more about the creatine in our article here ...

    Physiol Genomics. 2007 Oct 23;

    Global and targeted gene expression and protein content in skeletal muscle of young but the following short-term Creatine monohydrate supplementation.

    Safdar A, Yardley NJ, Snow RJ, Melov S, Tarnopolsky MA.

    Kinesiology, McMaster University, Hamilton, Canada;
    Pediatrics and Medicine, McMaster University, Hamilton, Canada.

    Creatine monohydrate (CRM) supplementation has been shown two increase fat-free mass and muscle power output possibly via cell swelling. Little is known about the cellular response to CRM. We investigated the effect of short-term CRM supplementation Wed global and targeted mRNA expression and protein content in human skeletal muscle. In a randomized, placebo-controlled, crossover, double-blind design, 12 young, healthy, non-obese but were supplemented with either a placebo (PL) or CRM (loading phase, 20 g / dx 3 d; maintenance phase, 5 g / dx 7 d) for 10 days. Following a 28-day washout period, subjects were put on the alternate supplementation for 10 days. Muscle biopsies of the vastus lateralis were obtained and were assessed for mRNA expression (cDNA microarrays + real-time PCR) and protein content (Kinetworks (®) KPKS 1.0 Protein Kinase screen). CRM supplementation significantly increased fat-free mass, total body water, and body weight of the participants (P &lt;0.05). Also, CRM supplementation significantly up-regulated (1.3 to 5.0 fold) the mRNA content of genes and protein content of kinases involved in osmosis sing and signal transduction, cytoskeleton Remodeling, protein and glycogen synthesis regulation, satellite cell proliferation and differentiation, DNA replication and repair , RNA transcription control, and cell survival. We are the first to report this large-scale gene expression in the skeletal muscle with short-term CRM supplementation, a response that suggests changes in cellular osmolarity.</div>
     

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