I couldn't sleep, so started rambling as an arm-chair expert chiming in:
TLDR: Even with advanced lifters, I'd start with a vanilla 3xweek plan or 6xweek A/B plan. I think you'll be surprised that it works. I think the first cycle is the technically the most important because it gives you the framework. But, I think the 2nd and 3rd cycle end up getting the best "gainz" because the weights end up being considerably higher.
If I can plan everything around training (not realistic for me), I'd do a 6xweek A/B plan. On the small chance vanilla doesn't work, there's probably an obvious reason (in order):
- sleep/diet
- underestimated rep maxes
- small chance it's not enough volume.
The stickied results thread is good if you're looking for something else, or Totentanz's book, or the simplify and win thread.
Long version:
My favorite plan is vanilla style 3xweek, but then after the 5s, do a DUP 6x/week plan increasing the weights on the 5s and 10s, but not paying attention on the high rep days. High rep (20-25), low rep (3-6), medium rep (9-12), then repeat for a few weeks before taking a week or two off.
Other fun plan I like:
Extending each rep range until completely maxed out, so the 15s may take 7 workouts, 10s, 8 workouts, etc. It's fun for a change, and likely trades the balance of diminishing results/hard work, so likely isn't as effective.
Other notes:
Ask, "how often am I going to workout over the next 6+ months?" Then put your plan together by balancing each muscle group at least 2x a week. Make sure to increase the weights cycle to cycle (regardless of which split).
Random notes:
"Back in the day," I "bulked" from 150 lbs to 185 lbs for high school football. The coaches had us maxing every workout on mainly a push/pull twice a week plan. 5x5, 6x4, 5/4/3/2/1, etc. After I was out of sports, I dropped down to 175 lbs fairly quickly (wasn't trying to). Got back into "serious" lifting, and I could do my own thing, so I tried most of the stuff on testosterone.net (back when it was updated only on Fridays, now t-nation.com). After a few years, and without force feeding myself, I was right around 185 lbs, but not considerably stronger.
I then stumbled across HST. Did a vanilla plan of:
Barbell rows
Shrugs
Squat
RDL
Bench press (usually, but not always, dumbbells for the 15s)
Pull ups (lat pull down for the 15s, then progress to weighted pullups for the 5s)
Leg curls (some times added weighted step ups before these)
Dips (or tricep pressdowns)
Lateral raises
Chin ups (or curls)
Within 12 weeks I was considerably stronger than before. It felt like all of a sudden, but it was probably 9 months or close to a year, I was at a lean 205 pounds. What? I'm bigger, stronger, and I haven't had to max out/bust my butt every workout AND I wasn't force-feeding myself? And, my shoulder/elbow/hip aren't killing me? I've since tried a lot of other programs for variety, and they just don't work as well for me.
Random:
Around 2006(?), I tried a cycle of 3xweek, twice per day, with repeating the AM workout in the late afternoon. Odd as it sounds, but the PM workout was easier than the AM workout. It worked, but didn't help my lower back/shoulder/elbow health. So, more effective now, doesn't mean better over 6 months.
So, the most effective plan is one that is consistently hits every muscle group at least 2x week, increasing the weights over time. Not just for a month or two, but over 6-12+ months.
I think the people that prefer HST and get the most out of it are the ones that have done multiple cycles of HST and are increasing the weight each cycle.