Ok, it was noted in another thread that high protein ingestion and also long term creatine ingestion may, let me stress may, cause renal system dysfunction. Now that I have a minute to address this let me say. The reason I am even posting this is I do not want anyone to get the assumption, from a few isolated case reports of renal dysfunction, that increased Protein or Creatine ingestion in and of itself is harmful when this isn't the case at all. But anyone concerned with this matter should seek their Doctor's advice. Protein-In a healthy population there is little conclusive evidence to support this. Proteinuria isn't absolutely identified yet as a cause of or simply a consequence of CKD. Most research sugesting reducing protein intake isn't based on healthy populations and those with normal filtration aren't affected by higher protein ingestion. Raila J, Forterre S, Schweigert FJ. [Physiologic and pathophysiologic fundamentals of proteinuria--a review] Berl Munch Tierarztl Wochenschr. 2005 May-Jun;118(5-6):229-39. Review. German. Mitch WE. Beneficial responses to modified diets in treating patients with chronic kidney disease. Kidney Int Suppl. 2005 Apr;(94):S133-5. Review. Kent PS. Integrating clinical nutrition practice guidelines in chronic kidney disease. Nutr Clin Pract. 2005 Apr;20(2):213-7. Review. Friedman AN. High-protein diets: potential effects on the kidney in renal health and disease. Am J Kidney Dis. 2004 Dec;44(6):950-62. Review. Zandi-Nejad K, Eddy AA, Glassock RJ, Brenner BM. Why is proteinuria an ominous biomarker of progressive kidney disease? Kidney Int Suppl. 2004 Nov;(92):S76-89. Review. Creatine-Pretty much the same, in a healthy person the risk associated with chronic creatine consumption has not been shown to cause much risk at all. Pline KA, Smith CL. The effect of creatine intake on renal function. Ann Pharmacother. 2005 Jun;39(6):1093-6. Epub 2005 May 10. Review. Yoshizumi WM, Tsourounis C. Effects of creatine supplementation on renal function. J Herb Pharmacother. 2004;4(1):1-7. Review. Poortmans JR, Francaux M. Adverse effects of creatine supplementation: fact or fiction? Sports Med. 2000 Sep;30(3):155-70. Review. Taes YE, Delanghe JR, Wuyts B, van de Voorde J, Lameire NH. Creatine supplementation does not affect kidney function in an animal model with pre-existing renal failure. Nephrol Dial Transplant. 2003 Feb;18(2):258-64. Robinson TM, Sewell DA, Casey A, Steenge G, Greenhaff PL. Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function. Br J Sports Med. 2000 Aug;34(4):284-8. Farquhar WB, Zambraski EJ. Effects of creatine use on the athlete's kidney. Curr Sports Med Rep. 2002 Apr;1(2):103-6. Review.