Calories are a determining factor in energy, but macros are also important for Protein Synthesis, Insulin, plus a whole website full of other factors. Don't forget we also get many minerals and vitamins based on certain foods which impact both calories and macronutrients. So it's the whole picture not just one aspect of it, including hormones. I believe, and someone please spank me if I assume too much, Bryan's stance is that the hormonal aspect of exercise is 1. Nothing we can control to any great degree, unless "assisted". 2. For the most part are going to do what we want anyway as long as we supply the correct set of stimulus.