This is one very interesting point Bryan state before the nutrition forum was reset. He says that hypertrophy is only dependent on a mechanical stimulus and incoming amino acids, not on insulin, carbs or fats. To me, protein are the materials, carbs do the building while fats ensure optimal hormone levels. I put more emphasis on getting enough carbs in my meals because of the thinking, " carbs release insulin which will shuttle amino acids to the muscle and without the "delivery", amino acids are useless even in giant amounts." I may have found the reason why i have not been growing optimally. This comment by Bryan gets me very excited. Can we conclude that the top priority of our diet is to get at least 1g of protein/lb of bodyweight or even higher for better results? Wouldnt there be a line crossed when even high amounts of protein cannot ensure hypertrophy because of drastic low caloric intake? I believe NightOp brought this point up. Suppose a 220lbs person maintenance is at 3000 calories. He gets AT LEAST 220g of protein but is eating only 2000 calories. Can hypertrophy still occur? (i know this is a poor example, but you get the concept. ) I am not saying we should just get our protein requirements right and forget about the rest of the diet. Bryan, it would be great if you can elaborate on this!!