I
imported_dkm1987
Guest
To put it in a nutshell.[b said:Quote[/b] (AShortt @ Jan. 24 2006,9:01)]What can I answer “specifically” for you?
It SEEMS to me that Johnston is using the signalling network involved with FAC via interaction of Integrins with a muscle pump. It's been shown many times that the cytoplasm of the cell can withstand minor cell volume/osmoality changes without effecting FAC signalling or cell survival(See Rennie's early work osmoality changes and their influence on Glycogen and Glutamine transport, Also see WU, Cheng, Ingber). If the human body was not able to withstand minor shifts in cell volume accompanied by minor osmoality change then apoptosis would occur much more frequently from these shifts. Now being that minor shifts in Oedema, Glycogen and Lactate occur with a pump I would like to know HOW Johnston is tying this together, and please don't quote Rennie's work again as I already have it and have read it many many times.
The reasoning given for line of pull (decrement of strength to increased size) isn't entirely accurate. It's seems that Johnston is negating the entire aspect of PCSA and only concentrating on whole muscle volume, this is misleading and inaccurate. It also appears he his negating the adapative response to chronic hypertrophy via changes in pennation and chronic neural efficiency increases that come with chronic training. So I would like for Johnston to explain to me how he came about to this conclusion. Please present scientific evidence of such.
Lastly, in the copy I have of J-Reps (be it an earlier release or not) he does say that fiber activation can be independant of MU activation and that this activation can be manipulated via varying the degree of the SSC. Now this could have simply been a misuse of terminology to try and make his point but still it isn't correct. Now if it is something that IART adheres to in a fundamantal belief then please present scientific evidence of such.
Now please do not insult my intelligence by simply regurgitating Johnston's comments from another source but please give me scientific rationale and preferably scientific evidence to support these positions.
Thank You
Dan