The fact is that heavy versus light weight really comes down to simple terms. The heavier the load, the more muscle fibers it will recruit. More recruitment means more hypertrophy. That's really how simple it is. You don't need to train with high reps for toning in order to hit the slow twitch fibers or any tricks to hit the fast twitch fibers. All fibers will get hit if you lift heavy enough. As Lol pointed out, lighter loads thus are less effective for overall hypertrophy unless you use certain tricks to try to optimize it, i.e. myo-reps, etc, which take advantage of the fact that as the muscle becomes fatigued, it is forced to recruit more fibers to lift the load. Therefore with a set using your 10 RM, as you progress through the set, eventually your muscles are forced to recruit all fibers to continue moving the load. Of course eventually the muscle will be incapable of lifting the load, which is failure, and something that we typically avoid here. Failure training does have it's place in enhancing strength however when it comes to hypertrophy, it is not necessary.
Now with a 5 RM load, you are going to be recruiting all fibers from pretty much the first rep. This is where something like Lol suggested where you do triples with your 5 RM is a sensible way to keep volume high enough to attain growth. And this is where we come back to the strength vs hypertrophy thing. Heavier reps with very low volume is good for strength but not so good for hypertrophy. A minimum amount of volume is typically necessary for growth and of course this is dependent on training age despite that study stating that 30 reps across the board is ideal. As we all know, someone early on in their training career will grow from less volume, someone more advanced will need more.
So to summarize... high reps with low load will not result in as much myofibrillar hypertrophy as using heavier loads. And the heavier the load, the more muscle fibers will be recruited throughout the set. This means that with a 15 RM load, we are probably only getting full recruitment on the last couple reps of a set, maybe on a second set we may get a few more reps at full recruitment. With a 10 RM load, we get a bit more, with a 5 RM load we will get full recruitment from the first rep. We obviously want to recruit all fibers for better hypertrophy. We need volume to be high enough to get some amount of growth as well.
But what about erk 1/2? It is unclear whether this actually genuinely enhances growth, but the take home point here is that training for erk 1/2 signalling alone will result in inferior growth compared to training heavier. If you want to try to optimize growth, then include some high rep stuff
alongside the heavy stuff. I do this by including 10-15 rep sets with a lighter load after I do my heavy work.
I don't think it is ideal to think of HST as using light loads for two weeks, medium loads for two weeks then heavy loads after that, or thinking in terms of high reps, mid reps and low reps. This leads to the thinking that Bryan included all these rep ranges in HST for reasons that he did not. HST is not about including all rep ranges for a balanced physique or to hit all muscle fibers or anything like that. HST is simply about starting at a percentage of your maxes, with a load that is just high enough to cause growth, and progressing upward from there. The reason we progress is because it allows us to grow for longer periods and it gives the joints time to strengthen themselves so they can keep up with our muscles. Endless cycles of only 5s will result in joints that are lagging behind your muscles and will start to feel beaten up after a while. You also keep yourself much closer to RBE which means you risk hitting a plateau sooner. 15s, 10s and 5s are simply a way of organizing your cycle, it's not because 15s are good for toning, 10s for hypertrophy and 5s for strength. Truth is, the 5s for best for toning, since using 5s while dieting will allow you to retain more muscle mass while losing fat than if you used lighter loads. 5s are best for hypertrophy because they recruit more muscle fibers than lighter loads, resulting in a higher growth signal. And 5s are best for strength as well when compared to ligher loads.
Here is a quote from Bryan where he cites a very important study about this issue:
Now, I will refer people to a study that was done comparing 3 different routines. (Campos GE, Luecke TJ, Wendeln HK, Toma K, Hagerman FC, Murray TF, Ragg KE, Ratamess NA, Kraemer WJ, Staron RS. Muscular adaptations in response to three different resistance-training regimens: specificity of repetition maximum training zones. Eur J Appl Physiol. 2002 Nov;88(1-2):50-60.) They used an 8-week high-intensity training program for the legs. Workouts were performed 2 days/week for the first 4 weeks and 3 days/week for the final 4 weeks. The subjects used one of three different regimens. The different training regimens were designed to be approximately equal in volume (resistance x repetitions x sets) with the rest periods between sets and exercises adjusted according to the strength-endurance continuum. Therefore, those individuals working on the high-rep end of the continuum performed fewer sets and had shorter rest periods compared with the other training groups.
The exercises were performed in the fixed order of leg press, squat, and knee extension. After warming up:
· The Low-Rep group used their 3-5RM for four sets with 3 min rest between sets and exercises.
· The Intermediate-Rep group used their 9-11RM for three sets with 2 min rest.
· The High-Rep group used their 20-28 RM for two sets with 1 min rest.
During the study, the resistance was progressively increased as subjects were able to perform more reps in order to ensure subjects were always using their true RM for each rep range.
So what happened? Did the type-I fibers increase most in the high-rep group? Did only the type-II fibers hypertrophy in the low rep group? If you believe you must do high reps for type-I fibers to grow and low reps for type-II fibers to grow then that’s exactly what should have happened.
On the other hand, if hypertrophy is a matter of load, and all fibers hypertrophy in response to increasing load, then hypertrophy should go up as load goes up. In other words the group that lifted the heaviest relative weight should have experienced the greatest amount of hypertrophy in ALL fiber types irrespective of the number of reps (within reason). And that is exactly what happened.
Here is a breakdown of the hypertrophy caused by each rep range. [Remember, each group trained to failure regardless of RM used so muscular fatigue was equal between groups.]
High-Rep (20-28RM)
Type-I
· pre = 3894 post = 4297 (10.3% increase)
Type-IIA
· pre = 5217 post = 5633 (8.0% increase)
Type-IIB
· pre = 4564 post = 5181 (13.5% increase)
Med-Rep (9-11RM)
Type-I
· pre = 4155 post = 4701 (13.1% increase)
Type-IIA
· pre = 5238 post = 6090 (16.3% increase)
Type-IIB
· pre = 4556 post = 5798 (27.3% increase)
Low-Rep (3-5RM)
Type-I
· pre = 4869 post = 5475 (12.4% increase)
Type-IIA
· pre = 5615 post = 6903 (22.9% increase)
Type-IIB
· pre = 4926 post = 6171 (25.3% increase)
Should this surprise anybody? No, Higher loads with equivalent volume leads to greater hypertrophy regardless of fiber type. It also doesn’t surprise me that these researchers were confused by the fact that the low rep group had as much or more hypertrophy that the other groups. They too have the idea cemented in their brain that you can’t use heavy weight to stimulate hypertrophy. The strength training dogma of the past has deeply influenced even the research community with regard to hypertrophy. This has done nothing but hinder their progress in understanding it because they end up designing studies on false premises.
I’m not sure why people are so hesitant to accept the preeminence of load for producing hypertrophy. Perhaps it is that they fear not growing as fast as they think they can.
It would be of much greater benefit for people to discuss issues of fiber type with regard to muscle “performance” (i.e. strength/endurance/power). After all, the very distinctions themselves are based on how the fibers used fuel, not how they respond to load. Hence, basing predicted hypertrophic outcomes on the metabolic characteristics of a fiber will never lead anybody to a correct understanding of the mechanisms of hypertrophy.
So... pretty clear that it comes down to exercise selection for building a balanced physique. Genetics will influence this as well.