"Overall, moderate volumes (≈30–60 repetitions per session for DER training) appear to yield the largest responses." An exception to this is with very high loads (90% 1RM or 120% to 230% 1RM with eccentrics) where high rates of growth have been shown with volumes as low as 12-14 repetitions per session. To date, relatively few studies have directly compared the effects of different volumes of work on the hypertrophic response as measured by scanning methodology." The paucity of data clearly warrants further research.
Preceded by ...
Results
No relationship could be found between frequency of training and the increase per day in muscle cross sectional area. When the intensity was plotted against the rate of increase, a weak tendency was found for the rate to increase with increasing intensity. The highest rates of increase tended to occur around 75% of 1RM. When volume was plotted against the rate of increase, greater gains in muscle mass were seen initially with increasing volume while there were diminishing returns as the volume increased further. The highest rates of increase tended to occur with 30-60 repetitions per session.
But then when I read the conclusion summary it says:
For the total volume or duration of activity, the results suggest a dose-response curve characterised by an increase in the rate of growth in the initial part of the curve, which is followed by the region of peak rate of increase, which in turn is followed by a plateau or even a decline. It is recognised that the conclusions drawn in this paper mainly concern relatively short-term training in previously untrained subjects and that in highly trained subjects or for training studies extending for several months, the dose-response trends and the hypertrophic effects of different modes and types of strength training may be very different.
All this says to me is that lighter loads need more repetitions to induce hypertrophy and that heavier weights induce more hypertrophy.
And then there's this:
Training Implications and Recommendations: For your typical "dynamic external resistance", recommendations are given for "Moderate load slow-speed training", "Conventional hypertrophy training", and "Eccentric (ecc) overload training". These three modes are denoted as suitable for beginners, novice-well trained, and advanced-elite, respectively. For the "Conventional hypertrophy training" for the novice to the well trained, they recommend an 8-10RM load (75-80% 1RM), with 8-10 reps to failure or near failure, 1-3 sets per exercise, progression from 1–2 to 3–6 sets total per muscle group, moderate velocity (1-2 seconds for each CON and ECC), 60-180 seconds rest between sets, and 2-3 sessions per muscle group per week
Which at worst appears contradictory to much of the information in their own study, or at best reads as a highly speculative derivative of the results.
Consider comparing the low and high points of their recommendations; 10RM load, 10 reps per set, 1 set per muscle group and twice per week. and then 8RM, 8 reps, 6 sets per muscle group, three times per week.
That's an extraordinary difference in workload.
Their own study says that 30-60reps produced the most hypertrophy,
except for 90% 1RM and 120-230% eccentrics, so why not use the result which actually produced the most hypertrophy ... ? Granted this isn't the actual study, and just a cut&paste of the most relevant paragraphs but still. It's disconcerting that they then make this statement
You often hear statements like "eccentric training produces the greatest muscle hypertrophy". "This review demonstrates that given sufficient frequency, intensity and duration of work, all three types of muscle actions can induce significant hypertrophy at impressive rates and that at present, there is insufficient evidence for the superiority of any mode and/or type of muscle action over other modes and types of training in this regard." In fact, the data suggest that pure eccentric training is inferior to both concentric and eccentric+concentric training, though this is still a subject of debate rather than a scientific certainty.
- so which is it?
Furthermore, the recommendations they have appear to be completely at odds with the training methods used by just about anyone who naturally (without chemical assistance) puts on significant muscle mass, including a significant # of lifters on this site.
And I guess the last issue I have with this study, beyond ancedotal experience (mine and reported by others here, elsewhere) is that it's still just one study and somewhat at odds with other studies. So which do you/we follow and how does one determine where the weight of authority falls?